The guidelines I always hear is that you can run 8.5:1 DCR with aluminum heads and 8:1 for iron heads. You need to target a .040 quench. Is the 220psi a measured number or a calc? What cam are you running? The other alternative to lowering the static compression is to run a cam with a later intake closing event.
You've specified your compression ratio as 10.27:1, and it doesn't really matter how you arrive at it. Small chambers, dished pisons, special gasket, etc., 10.27:1 is 10.27:1. I enter this in EA3.0 as the specified compression, along with the cam installed at 106° ICL and lashed at .015".
I have a 331" SBC with 10.8:1 compression and a TMR-50-4040-10A4 cam ( 269° @ .020", 240° @ .050" ) and it has 195# cranking compression.
EA3.0 figures my DCR at about 7.8. It's an aluminum headed engine. I wouldn't put too much emphasis on exact DCR unless you know exactly when the intake valve closes fully. Using advertised duration can be a little misleading, since many modern cams are lashed less than the tappet lift at the advertised duration.