If I read your engine information correctly, I calculate you have at least a 10.54:1 Static Compression with a .015" Deck and specs you have provided using Flat top Pistons allowing 5cc's for Valve reliefs.
With that 286H-10 cam, you would have approximately an 8.1:1 DCR with the cam installed at 106 Degrease, that is 4 degrease advanced, where 8.2 is considered about the MAX for street use on Pump Gas.
With a .012" Deck, the Static/DCR may be 10.6:1/8.15:1. I imagine other members will check my calculations - LOL
I personally would not run that engine with anything less then 91 Pump Octane which has is 95 RON and preferably Pump 93 which is approximately 97 RON.
This new GAS is Sh*T and it is very hard to hear Detonation until it is too late. The Hot Headers and Run On is an indication that you are detonating. Note: Run On can be caused from a vacuum leak, the throttle plates not closed enough and not enough advance; but heed the previous statement regarding detonation. Reports from many say Alu-Heads are better in regards to detonation over Cast.
In any account Pull the Plugs and look for the tell Tale Flecks on the Ceramic which indicate Detonation.
If you do not want to run 93, you may get by with 91 but I would try E5 or 10 as an alternative as the % ethanol will have a cooling effect and you should not have to make any induction changes in regards to Fuel Supply or Jetting (perhaps the next size larger). I'm not sure what the Pump or RON Octane rating of E5 or 10 is but typically rated as 2 to 3 octane higher than regular gasoline. The UK and Aussy E10 Blends are around 99 RON (Nice). Here's a descent article on E Fuels http://en.wikipedia.org/wiki/Common_...5.2C_E7.2C_E10
A 750 is not too big for a Hi-Perf Mechanical Cammed 327 at the strip and no too out of line on the street if jetted correctly where a 650 may be better suited for a lesser revving build. I personally run a Holley 750 Dp/Edelbrock RPM with Jenkin 291's which seems to respond better with the 750 on it then a similar built 350 using a 750. I can't say why but may have something to do with the over square specs and the way the motor demands to breath over 7000rpm - Gotta love the 327 ;o)
That is a nicely Spec'd 327 you have with a .037 or .040" quench and.025" Compo-Gaskets for them Alu-Heads. You might think about Shaft Rockers with a Mechanical or SR Cam in the future.