Technically putting a fuse in place of a fusable link would be safe. However, fusable links are much more forgiving than a fuse. Why do you want to do this? Fusable links are cheap and work well for high current power sources.
They also have them at NAPA parts stores. I've had to stick fuses instead of links at least a few times to get junk running. Like dnult said though, the link is sloblow. I think they look better than a fuseholder too.
Make sure to put those fusable links in a place where they can melt down without starting a fire. Never bundle them together or tape them up with other wires. Let them hang free. As others have said, near the power source is where they belong.
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