If you are starting with flat tops then you don't want or need 781's or 049's. They are 116-122cc's stock and would cost you more than a set of new aftermarket small chamber heads to get to a usable size for you. Waste of time and money due to the fact that you would need extensive milling, porting, bigger valves etc...
They can be great heads for a higher compression engine, I ran 781's with 540+ hp, but they like compression.
You probably need a head closer to the 100cc range. Heads, cam and good smaller tube headers will get you over 500 hp done right but 650 hp on flat tops will take some work with a BIG solid roller cam, great heads, bigger headers, 3 in. exhaust and probably soft until 3500 rpm.
I personally think if you get over 500hp and can use it to hook you will be more than happy. This is if you are using your car on the street of course. Track is a different story.