A properly rebuilt Quadrajet that has been tuned to meet your engine's requirements makes all the difference in the world when compared to a corner store rebuild that is a mish mash of "good" parts from the many different cfm ratings and styles that were made over the years. Just because a part will fit inside the carb doesn't make it the correct part for the application. GM made seven different cfm rated carbs to fit a CHEVY (excluding the BOP carbs that had a different fuel inlet) and externally they all look alike. The springs to open the back barrels, the jets, rods, and boosters, as well as the venturi size all differ between the various models. You can not mix and match parts the way a woman sitting on a bench in Calacutta would do fitting a "rebuilt" carburetor together according to a picture on the wall before her.
The change in the manifold would be the biggest gain. First an aluminum manifold is lighter and every pound you drag around wastes gas and hurts your ET. Second point is the original manifold was designed for reduce cost in production man hours to roll the green sand on a bench and assemble a manifold from the component hand made parts. The newer manifolds were designed on a "Super Computer" (Edelbrock rented time on one just to simulate the wet fluid flow characteristics) which allows their new Edelbrock RPM Air Gap dual plane manifold to flow as well as the older Edelbrock Victor Junior single plane manifold; and still retain all of the advantages of a dual plane manifold. Edelbrock spent the R&D money and cast their parts using lost wax technology here in the US. That didn't stop the Chinese who have since copied them: as have most of the industry to one degree of success or another.
As to the carburetor size and brand, once again smaller is better for the street. Consider how much time you are going to spend driving o the street compared to track time. You change tires to race why not a carb? As to brand I use a Holley, I have been using them since 1963 when I got tired of multiple carbs on top of my 409. Carter didn't make one carb big enough back then, but Holley did (it was used on the Ford NASCAR entry). Holley has had a Ford throttle lever ever since; and it has to be adapted (you use a special bushing) to work with a Chevy, which still irritates me. One big carb is much easier to tune than two or three smaller ones (which is why I threw a Corvette manifold, three Holley two barrels and the linkage along with the air cleaner in the trash and buried it my back yard when I bought a 1967 427 L-71 motor for my Camaro).
The Holley will not make one horsepower more than a properly tuned Edelbrock (CarterAFB) or a Rochester QuadraJet or a brace of similar size (cfm rated) Weber carbs. All will mix air and fuel to the same ratio of air and gas to burn in the engine. If you want the most expensive carb on the planet that is used in place of EFI on many sports cars because it can be so completely tuned that every part can be tailored to match the car's needs. Four Weber DCOE carbs and manifold for a BBC will set you back $3,600. It won't make any more power than Holley Dominator but it looks totally cool.
Big Dave