The actuators are a 5 wire setup and while they basically do the same thing as a 2 wire actuator with locking and unlocking the doors, the 5 wires offer a feature that if one door is locked or unlocked manually it sends an electronic signal to the other actuator to have it do the same thing.
Without looking at the wiring diagram, both doors may lock and unlock with the remote but better systems when both doors are locked and you press the remote unlock button just the driver's door unlocks and then a second push unlocks the other door.
If your car does not have power windows or locks in it now, then the doors and cowl side will have to be drilled to install rubber door grommet tubes. To make the holes the doors may have to come off. Hard telling what you are putting this into as you did not supply that info.
When you do install this system, leave the door panels off to where if something screws up you can get inside the door to work on things and not fight trying to take the door panel off on a closed and locked door.
It might also be a good time to remove the door latch/lock mechanisms and clean them and then after checking for any excessive wear, lube them back up.
Jim